Diabetes is a worldwide problem caused due to metabolic disorder. Stomach converts food to glucose which is then broken down by insulin. When insulin is resistant or inadequate, there is an increase in the blood sugar levels. This results in Diabetes Type II. ACTOS is a medication used in the treatment of Type II Diabetes. Pioglitazone hydrochloride, the chemical name of ACTOS is an odorless white crystalline powder. It is available in a tablet form. ACTOS can also be used in combination with insulin.
Physiology of ACTOS:
ACTOS is used to lower blood sugar levels. It helps the body to utilize the insulin produced efficiently and stops the liver from making more sugar. This helps the sugar to move from the bloodstream to other parts of the body. There is no build –up of sugar in the bloodstream, thus lowering the blood sugar levels.
Dosage and Use of ACTOS:
ACTOS is a pill available as 15mg, 30mg and 45mg. The recommended dose is one 15mg or 30mg tablet daily. It is recommended only to patients without congestive heart failure and must be taken as prescribed by a doctor or a physician.
This is an oral medication that can be taken with or without food. Medication must be taken regularly and at the same time daily. Blood sugar must be monitored regularly. Your dosage and treatment may be changed by your doctor or physician as per your results. ACTOS takes around 2 to3 months to show its affect. The therapy also includes exercise, healthy diet, weight control and regular health check-ups.
ACTOS is stored at 25°C (77°F) in air tight containers and kept away from sunlight, moisture and humidity.
Side-Effects of ACTOS:
You will require immediate medical attention if you show any of the following side effects
- Stomach aches
- Swelling or increased weight gain
- Blurred vision
- Painful urination/blood in urine
- Nausea
- Jaundice
- Increased thirst, hunger and urination
- Chest pain
- Fatigue
- Wheezing
Some of the less serious side effects of ACTOS are:
- Colds
- Headaches
- Back aches
- Tooth decays
- Muscle pain
- Weight gain
Some people are allergic to Pioglitazone. Some of the allergic reactions seen are hives, wheezing, swelling in lips, face or tongue and dizziness. Allergic reaction will require immediate medical attention.
Precaution:
Congestive Heart Failure: ACTOS is known to cause water retention. This leads to edema and in severe cases may lead to congestive heart diseases.
Hepatitis: Liver diseases have been reported in patients taking ACTOS. There is no supporting evidence for this. Patients with abnormal liver tests must not take ACTOS.
Fractures: During a study it was seen that female patients under ACTOS medication have shown some nonvertebral fractures. The risk of fractures must be considered before administering ACTOS.
Urinary Bladder Tumor: A carcinogenicity research has shown tumors in the urinary bladder of male rats. Further studies have shown urinary bladder tumors in patients taking ACTOS. The studies are still ongoing and there are no conclusive data to prove ACTOS as a tumor promoter.
Hypoglycemia: Hypoglycemia is a medical term for blood sugar levels lower than normal. ACTOS has caused hypoglycemia in few patients. Always keep some source of sugar with you if you are taking ACTOS.
Ovulation: Women on ACTOS therapy has shown to ovulate. They are at an increased risk of pregnancy.
Pregnancy: Animal studies have shown reduction in fetal weight, delayed development, and implantation failure when medicated with ACTOS. There is no evidence of its impact on human beings, but it is best avoided during pregnancy to avoid possible risk to the fetus
Nursing mothers: As all the other drugs, ACTOS is also secreted in milk. ACTOS can cause potential adverse events in nursing infants, it is best to avoid it.
Alcohol: Alcohol lowers blood sugar levels. Taking alcohol during an ACTOS medication cycle can have adverse effects.
Thiazolidinediones (TZDs)
Thiazolidinediones (TZDs) are a group of medication used to treat Diabetes mellitus type II. Investigations on the use of TZDs are being conducted. The main side effect of TDZs is edema or water retention. Some of the other side effects of TZDs are hepatitis and potential liver failure, Heart failure, plaques and coronary heart diseases.
FAQS
How should I take ACTOS?
You should take the medication as prescribed by the doctor or physician. Avoid self medication. Monitor your blood sugar levels regularly. Check for signs for hypoglycemia. ACTOS can be taken with or without food.
What happens if you miss a dose?
The missed dose should be taken immediately. If you remember to take the dose closer to the next dose time, skip one tablet. Do not overmedicate.
What happens when I overdose?
You need medical attention if you have had an overdose of ACTOS. Check for signs of hypoglycemia such as fatigue, blurred vision, sweating, tremors, stomach ache, dizziness and allergic reactions.
